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What Is Next-Generation Sequencing

NGS is the abbreviation for a DNA sequencing technology known as next-generation sequencing. DNA sequencing is done on a large scale and allows for genes to be sequenced in three different ways. Next-Generation sequencing can sequence the entire genome, exons of selected genes, or the entire genome. When the entire genome is sequenced, it is known as the sequencing of the whole genome. When the exon of selected genes is sequenced, it is known as the sequencing of the target panel. When the exons within all genes are sequenced, it is known as the whole exome.

NGS can be performed on almost any type of species. The technology has advanced since its first discovery. Because of the advancement and different types of next-generation sequencing, categories in technologies available are being used across various scientific and medical platforms. Two of the most common categories that are used in NGA technology are de novo approaches and reference-based. Of these two categories, the reference-based approach is easier to use. The de novo approach is used to reassemble any genomes that have been altered.

The History Of Next-Generation Sequencing

NGS was introduced onto the market for commercial use back in 2005. The sequencing initially was not called next-generation sequencing, but instead, it was called massively parallel sequencing. When this sequencing was created, the sole purpose was to study DNA or RNA and their association with diseases or any biological abnormalities. Next-Generation sequencing is considered the top form of sequencing on the market. What makes next-generation sequencing the best is that it has a unique capability of sequencing thousands of genes at one time by using multiple samples.

Next-Generation sequencing has only been on the commercial market for about 16 years and has risen to be one of the top sequencing processes used in microbiology and science. Next-Generation sequencing is vital in learning about different diseases and biological abnormalities such as cancer. This type of gene sequencing allows science and medical professionals to create cures and preventive measures for chronic and life-threatening illnesses.